Preparation and In vitro Characterization of Alprazolam Extended- Release Tablets Using HPMC 4000cps

Authors

  • Mahsa Hedayatzadeh Department of Pharmaceutics, Pharmaceutical Sciences Branch, Islamic Azad University (IAUPS), Tehran, Iran
  • Mohammad Reza Avadi Department of Nanotechnology, Pharmaceutical Sciences Branch, Islamic Azad University (IAUPS), Tehran, Iran
Abstract:

The main aim of this study was preparation and evaluation of extended - release system ofthe anxiolytic substance. Alprazolam is a short-acting benzodiazepine with general propertiessimilar to those of diazepam. Our studies focused on development of extended drug deliverysystem based on Hydroxy Propyl Methyl Cellulose (HPMC 4000cps) as retard agent andPolyvinylpyrrolidone (PVP k30) as binder using factorial design. All prepared matrix tabletswere considered for physicochemical evaluation and drug content. In vitro release study ofmatrix tablets for all formulations has shown that HPMC is the main component in retarding ofalprazolam in dissolution medium. The optimum formulation (30% HPMC 4000 and 10% PVP)with suitable release profile according to criteria of United State Pharmacopoeia has selected forstability studies according to ICH guidelines.

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Journal title

volume 4  issue 1

pages  43- 52

publication date 2016-06-19

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